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Classical drug discovery uses 2D cell culture coupled with animal testing for preclinical studies. Neither 2D cell culture nor animal testing truly recapitulate the in vivo microenvironments of cells in a human body. Using 3D cell culture in lab-on-a- chip devices that can faithfully mimic the in vivo conditions, costs can be reduced ten-fold, results can be achieved ten times faster, animal testing can be significantly reduced and personalized medicine can be realized.
Devrim will present new lab-on-a-chip devices/assays for investigating (i) distance dependent interactions such as juxtacrine and autocrine signaling and (ii) invasion and chemotaxis with a focus on cancer cell biology.